Systemic Lupus Erythematosus
Rheumatology · Systemic Lupus Erythematosus 🎯 Practice these cards
SLE affects women far more often than men, with a female-to-male ratio of approximately ____.
SLE affects women far more often than men, with a female-to-male ratio of approximately 9:1, typically presenting between ages 15 and 45.
The 2019 EULAR/ACR SLE classification criteria require ANA at a titer of at least ____ as the entry criterion.
The 2019 EULAR/ACR SLE classification criteria require ANA at a titer of at least 1:80 (on at least one occasion) as the single entry criterion.
Under the 2019 EULAR/ACR criteria, a score of ____ or more points classifies SLE.
Under the 2019 EULAR/ACR criteria, a score of 10 or more points (with at least one clinical criterion) classifies a patient as having SLE.
The most specific autoantibody for SLE is anti-____.
Anti-Smith (anti-Sm) antibody is the most specific autoantibody for SLE, though present in only ~25% of patients and not activity-related.
The autoantibody whose titers often parallel disease activity and correlate with nephritis is anti-____.
Anti-dsDNA titers often parallel disease activity and correlate with nephritis, making them useful for monitoring flares.
The main long-term toxicity of hydroxychloroquine requiring ophthalmologic screening is ____.
The main long-term toxicity of hydroxychloroquine is retinal maculopathy, requiring baseline ophthalmologic screening and annual screening after 5 years.
EULAR 2023 guidance aims to minimize prednisone maintenance to ____ mg/day or less.
EULAR 2023 guidance frames SLE management around a treat-to-target goal (remission or low disease activity) and aims to minimize prednisone maintenance to 5 mg/day or less.
In the REGENCY trial, obinutuzumab raised complete renal response at week 76 to ____% versus 33.1% with standard therapy.
In the phase 3 REGENCY trial, obinutuzumab raised complete renal response at week 76 to 46.4% versus 33.1% with standard therapy alone in active lupus nephritis.
The most common and most aggressive lupus nephritis is class III (focal) and class ____ (diffuse) proliferative nephritis.
Class IV (diffuse) proliferative lupus nephritis is the most common and most aggressive form, requiring induction immunosuppression.
For antiphospholipid thrombosis, anticoagulate with a vitamin K antagonist (____), not a DOAC.
For antiphospholipid thrombosis, anticoagulate with a vitamin K antagonist (warfarin), not a DOAC—DOACs are inferior in antiphospholipid syndrome.
Tap a card to flip it.